Ciclosporin: dosage and price

Ciclosporin: dosage and price

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There cyclosporine is a drug that can be used by those who have undergone an organ transplant but also by those suffering from disorders of the psoriasis and dermatitis. It depends on the dosage and the effects you want to achieve, the important thing is to listen to the doctor's instructions and warn him if you feel any unwanted effects, even if it is not a generally poorly tolerated drug.

Ciclosporin drug

Cyclosporine, when it acts on our body, decreases the activity of the immune system, a system in charge of defending the body from everything foreign to it. This is why it is used by those who have suffered a organ transplant, to ensure that the body does not reject it, whether it is a heart, a liver, a kidney or whatever. The same drug, for different reasons, is also used to treat other diseases that are not very relevant to transplants, such as psoriasis, some forms of dermatitis, uveitis and nephrotic syndrome.

Ciclosporin: dosage

This drug can be sold and taken as solution or in soft capsules, also exists in intravenous infusion vials but is used only by qualified personnel. It is very important, with the cyclosporine, follow the doses indicated by the doctor without changing them or even interrupting the treatment, the best thing is to set a time during the day and always take the daily dose to not forget.

Sometimes we forget a dose, we try to recover as soon as possible but if it is already time for the next dose, it is better to continue with that and not take a double dose within a few hours.

When we have to take the oral solution we can find ways to make its taste more pleasant by mixing it with milk, milk and chocolate or orange juice at room temperature, in a glass and not a plastic beaker. We avoid grapefruit juice and drink immediately after mixing by rinsing the glass with a little water and drinking this too. If instead we have chosen the version in capsules, let's not break them and chew them, they should be taken whole, preferably after meals to minimize the risk of stomach upset.

When the doctor prescribes this drug, he must be absolutely aware of all the drugs we are taking because the cyclosporine can interact with it. It is also important to report if you have severe kidney or liver disease, if you suffer from high blood pressure, if you suffer from convulsions, if we have had any "allergies" to drugs or to some other substance. Even during pregnancy and breastfeeding it is good to inform the doctor who will evaluate what to do.

Ciclosporin: psoriasis

Cyclosporine can be well used too to treat psoriasis as well as other immune diseases such as uveitis, rheumatoid arthritis and ulcerative colitis. There are cases in which it has been used with great success even by those who suffered from severe forms of asthma or atopic dermatitis.

The main indication of the cyclosporine is and remains the prevention of rejection in organ transplantation, it is used in particular in kidney, pancreas, liver and heart transplants. It is an alternative to tacrolimus, the two drugs in fact have a similar mechanism of action and can be used both individually and in combination with other immunosuppressive drugs.

Ciclosporin: disorders

Normally cyclosporine is a well tolerated drug but this does not cancel the probability of onset of some disorders, the famous side effects that almost every drug has. In this case, you may notice an excessive growth of hair and hair, tremors, an increase in blood pressure, a feeling of tiredness and increased susceptibility to infections.

Undesirable effects include nausea, vomiting, stomach pain but also mental confusion, convulsions, hallucinations, anxiety, weakness, headache. It is true that cyclosporine treats some skin disorders but it can also cause them, they can in fact appear redness, itching, bleeding or unusual bruises. Swelling and bleeding of the gums can also be a drug disorder.

Ciclosporin: how it works

Both cyclosporine and tacrolimus they are both defined as calcineurin inhibitors. Let's see why. Both block the transcription of cytokine genes in T lymphocytes after interaction with a cytoplasmic protein known as cyclophilin A. This mechanism inhibits the protein phosphatase 2B also called calcineurin (PP2B), which dephosphorylates the transcription factor NF-AT (nuclear factor of activated T lymphocytes) allowing it to enter the nucleus. If NF-AT is not dephosphorylated, it cannot enter the nucleus and trigger the gene expression of certain cytokines such as interleukin 2 (IL-2).

According to a recent study, the cyclosporine it also interferes with another transcription factor called NF-κB (Nuclear factor of antibody light chains κ), always involved in the gene expression of inflammatory and immune proteins.

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Video: Cyclosporine Mnemonic for USMLE (May 2022).


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